Isolation and structure of peptaibolin, a new peptaibol from Sepedonium strains.

peptaibols in microbial culture extracts3~5). Here we report the isolation and structure elucidation of peptaibolin (1, Fig. 1) as an unusual representative of the peptaibol family of lipophilic antibiotics. 1 was disclosed in two fungal strains, Sepedonium sp. HKI-0117 and Sepedonium ampullosporum HKI-0053 coproducing the neuroleptic peptaibol-type antibiotic ampullosporin5). In contrast to the known peptaibols6), the compound 1 contains only five peptide bonds. However, it displays all of the structural features of the